PPP2R3C

Across TCGA pan-cancer cohorts, PPP2R3C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP2R3C data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PPP2R3C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP2R3C expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LSCC, LUAD, and GBM are the cancer types where PPP2R3C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.626	0.918	<.001	38	view →
LUAD	OS	Quartile	II,III,IV	0.703	0.289	.014	18	view →
GBM	OS	Quartile	All	0.816	1.000	.014	6	view →
UCEC	DFS	Median	All	1.000	0.941	.048	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP2R3C–LSCC (DFS)

Open the LSCC breakdown →