PPP2R3C

Across TCGA patient cohorts, PPP2R3C mutation is significantly associated with the RNA expression of many other genes, with 2,446 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R3C-associated genes across cancer lineages are RN7SL185P, C9orf62, and RNU6-340P. Each is linked with PPP2R3C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R3C-to-partner and partner-to-PPP2R3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL185P grouped by PPP2R3C-low versus PPP2R3C-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R3C→partner) and Y-score (partner→PPP2R3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL185P →	+0.134	+7.954	<.001	.008	3	2
UCEC	C9orf62 →	+0.062	+2.304	.003	.005	3	2
CESC	RNU6-340P →	+0.364	+5.342	<.001	.002	3	2
LUAD	RNA5SP408 →	+0.308	+7.930	<.001	.008	3	2
UCEC	IL21 →	+0.121	+2.316	.001	<.001	3	2
UCEC	RNA5SP412 →	+0.675	+2.074	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,446 associations by consensus.

RN7SL185P by PPP2R3C expression — HNSC

Explore this box plot interactively →