PPP2R3C

Across TCGA patient cohorts, PPP2R3C mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R3C-associated genes across cancer lineages are ATM, Cyclin-E2, and EGFR_pY1068. Each is linked with PPP2R3C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R3C-to-partner and partner-to-PPP2R3C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PPP2R3C-low versus PPP2R3C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R3C→partner) and Y-score (partner→PPP2R3C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.540	-2.000	.008	.032	3	2
UCEC	Cyclin-E2 →	+0.191	+3.169	.011	.018	3	2
UCEC	EGFR_pY1068 →	-0.279	-2.000	.013	.032	3	1
UCEC	eIF4E →	+0.203	+2.700	.033	.006	3	1
UCEC	eIF4G →	+0.320	+2.999	.022	.035	3	1
UCEC	FoxM1 →	+0.378	+3.331	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ATM by PPP2R3C expression — UCEC

Explore this box plot interactively →