PPP2R3B

Across TCGA pan-cancer cohorts, PPP2R3B Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP2R3B data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPP2R3B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPP2R3B expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

HNSC, ESCA, and PAAD are the cancer types where PPP2R3B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.710	.002	24	view →
ESCA	DFS	Median	II,III,IV	0.506	0.316	<.001	16	view →
PAAD	DFS	Median	All	0.079	0.484	<.001	12	view →
BLCA	OS	Median	IV	0.051	0.600	<.001	12	view →
SKCM	OS	Median	III,IV	0.230	0.721	.004	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	DFS	Median	All	0.209	0.659	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP2R3B–HNSC (OS)

Open the HNSC breakdown →