PPP2R3A

Across TCGA patient cohorts, PPP2R3A mutation is significantly associated with the RNA expression of many other genes, with 3,638 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R3A-associated genes across cancer lineages are DOC2B, CDC7, and FOCAD-AS1. Each is linked with PPP2R3A in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP2R3A-to-partner and partner-to-PPP2R3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOC2B grouped by PPP2R3A-low versus PPP2R3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R3A→partner) and Y-score (partner→PPP2R3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOC2B →	-1.047	-2.129	<.001	<.001	3	3
UCEC	CDC7 →	+0.602	+2.066	<.001	<.001	3	3
UCEC	FOCAD-AS1 →	+0.417	+2.394	<.001	<.001	3	3
UCEC	CYP2T1P →	-0.585	-2.392	<.001	<.001	3	3
UCEC	CACTIN →	+0.389	+1.928	<.001	<.001	3	3
UCEC	FNDC4 →	-0.458	-1.699	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,638 associations by consensus.

DOC2B by PPP2R3A expression — UCEC

Explore this box plot interactively →