PPP2R3A

Across TCGA patient cohorts, PPP2R3A mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R3A-associated genes across cancer lineages are TFRC, Tuberin_pT1462, and EGFR_pY1068. Each is linked with PPP2R3A in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP2R3A-to-partner and partner-to-PPP2R3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by PPP2R3A-low versus PPP2R3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R3A→partner) and Y-score (partner→PPP2R3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.494	+2.502	.001	.001	3	3
BLCA	Tuberin_pT1462 →	-0.233	-3.152	.002	.019	3	2
UCEC	EGFR_pY1068 →	-0.274	-2.050	<.001	<.001	3	2
UCEC	FoxM1 →	+0.206	+2.050	.007	<.001	3	2
UCEC	ACC1 →	+0.267	+2.128	.013	.009	3	2
UCEC	mTOR_pS2448 →	-0.146	-2.156	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

TFRC by PPP2R3A expression — UCEC

Explore this box plot interactively →