PPP2R3A

Across TCGA cell cohorts, PPP2R3A mutation is significantly associated with the RNA expression of many other genes, with 476 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP2R3A-associated genes across cancer lineages are C6orf118, CREB3, and ASB3. Each is linked with PPP2R3A in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP2R3A-to-partner and partner-to-PPP2R3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by PPP2R3A-low versus PPP2R3A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R3A→partner) and Y-score (partner→PPP2R3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.112	+2.793	<.001	.002	3	2
BLOOD_Leukemia	CREB3 →	+0.636	+3.351	<.001	.003	3	2
BLOOD_Leukemia	ASB3 →	+0.486	+3.115	.004	.009	3	2
BLOOD_Leukemia	LANCL1 →	+0.744	+3.351	.002	.003	3	2
BLOOD_Leukemia	TEKT3 →	+0.180	+3.775	.004	.001	3	2
BLOOD_Leukemia	TTI2 →	+0.487	+3.351	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 476 associations by consensus.

C6orf118 by PPP2R3A expression — LARGE_INTESTINE

Explore this box plot interactively →