Across TCGA pan-cancer cohorts, PPP2R2A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP2R2A data layer compared with 19 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPP2R2A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP2R2A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where PPP2R2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	1.000	0.733	.001	27	view →
HNSC	OS	Median	IV	0.894	0.615	.010	13	view →
PDAC	OS	Tertile	IV	0.414	0.973	.024	9	view →
LSCC	OS	Tertile	II,III,IV	0.713	0.956	.029	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PPP2R2A tumor-vs-normal RNA expression · all PPP2R2A data types