PPP2R2A

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PPP2R2A mutation is significantly associated with the RNA expression of many other genes, with 2,086 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R2A-associated genes across cancer lineages are TTTY5, FGFR3P5, and CCL27. Each is linked with PPP2R2A in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP2R2A-to-partner and partner-to-PPP2R2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R2A→partner) and Y-score (partner→PPP2R2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LIHCTTTY5 →+0.041+5.878<.001.00233
LIHCFGFR3P5 →+0.072+6.676<.001<.00132
CESCCCL27 →+0.094+5.812<.001.00332
CESCRN7SKP152 →+0.258+6.569<.001.00132
CESCTRIM64EP →+0.071+5.969<.001.00232
CESCRPL17P14 →+0.090+5.969<.001.00232
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,086 associations by consensus.

Exploration