Across TCGA patient cohorts, PPP2R2A mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP2R2A-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and Acetyl-a-Tubulin-Lys40. Each is linked with PPP2R2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP2R2A-to-partner and partner-to-PPP2R2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP2R2A→partner) and Y-score (partner→PPP2R2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.664	+2.720	.003	.003	3	2
UCEC	EGFR_pY1068 →	-0.303	-2.115	.001	.017	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.522	+2.087	.007	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.182	-2.000	.004	.030	3	1
UCEC	JNK2 →	+0.184	+2.469	.016	.010	3	1
UCEC	Ku80 →	+0.266	+2.598	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

PPP2R2A survival (RNA) · tumor vs normal (RNA) · all PPP2R2A data types