PPP2CB

Across TCGA pan-cancer cohorts, PPP2CB mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PPP2CB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPP2CB mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPP2CB is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and LSCC are the cancer types where PPP2CB tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP2CB mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.500	<.001	11	view →
CCRCC	Female	All	−0.331	<.001	11	view →
LSCC	Male	All	−0.533	<.001	8	view →
LUAD	Male	II,III,IV	−0.347	<.001	8	view →
HNSC	Male	All	−0.314	<.001	8	view →
PDAC	Male	II,III,IV	+0.845	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PPP2CB–COAD

Open the COAD breakdown →