PPP1R9A

Across TCGA pan-cancer cohorts, PPP1R9A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PPP1R9A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PPP1R9A RNA is repressed in tumor relative to normal tissue. In most cancer types PPP1R9A is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

KIRC, LUSC, and HNSC are the cancer types where PPP1R9A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R9A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.792	<.001	10	view →
LUSC	Female	II,III,IV	−1.751	<.001	8	view →
HNSC	All	All	−0.668	<.001	8	view →
CHOL	All	All	+2.854	<.001	5	view →
LIHC	All	All	+0.439	.002	4	view →
BRCA	Female	All	−0.376	.003	4	view →
PRAD	All	All	+0.934	<.001	2	view →
STAD	Male	IV	−1.059	.030	1	view →
KIRP	Female	All	+0.688	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PPP1R9A–KIRC

Open the KIRC breakdown →