PPP1R3D

Across TCGA pan-cancer cohorts, PPP1R3D mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP1R3D data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PPP1R3D mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R3D expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LUAD, UCEC, and HNSC are the cancer types where PPP1R3D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.265	0.751	.002	12	view →
UCEC	DFS	Median	II,III,IV	0.883	0.532	.020	4	view →
HNSC	OS	Median	II,III,IV	1.000	0.954	.023	3	view →
GBM	OS	Median	All	0.475	0.281	.027	3	view →
CCRCC	OS	Quartile	All	0.762	0.960	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPP1R3D–LUAD (DFS)

Open the LUAD breakdown →