PPP1R3C

Across TCGA pan-cancer cohorts, PPP1R3C Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PPP1R3C data layer compared with 25 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher PPP1R3C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPP1R3C expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

STAD, CHOL, and SKCM are the cancer types where PPP1R3C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.001	0.688	<.001	48	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
SKCM	DFS	Median	All	1.000	0.200	.018	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PPP1R3C–STAD (OS)

Open the STAD breakdown →