PPP1R3B

Across TCGA patient cohorts, PPP1R3B mutation is significantly associated with the RNA expression of many other genes, with 1,100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R3B-associated genes across cancer lineages are FAM177A1, DPH3, and LZIC. Each is linked with PPP1R3B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3B-to-partner and partner-to-PPP1R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM177A1 grouped by PPP1R3B-low versus PPP1R3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3B→partner) and Y-score (partner→PPP1R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM177A1 →	+0.451	+3.202	.002	.009	3	2
UCEC	DPH3 →	+0.555	+3.818	.001	<.001	3	2
UCEC	LZIC →	+0.666	+3.625	.001	.001	3	2
UCEC	SLBP →	+0.613	+3.475	.003	.002	3	2
UCEC	AIMP1 →	+0.431	+3.209	.009	.009	3	2
UCEC	METTL2B →	+0.435	+2.721	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,100 associations by consensus.

FAM177A1 by PPP1R3B expression — UCEC

Explore this box plot interactively →