PPP1R3B

Across TCGA patient cohorts, PPP1R3B mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R3B-associated genes across cancer lineages are Mesangial cells, pDC, and Smooth muscle. Each is linked with PPP1R3B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R3B-to-partner and partner-to-PPP1R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mesangial cells grouped by PPP1R3B-low versus PPP1R3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3B→partner) and Y-score (partner→PPP1R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Mesangial cells →	-0.051	-3.443	.003	.005	3	1
UCEC	pDC →	+0.081	+2.202	<.001	.033	3	1
SKCM	Smooth muscle →	+0.125	+3.006	.048	.020	2	1
SKCM	Erythrocytes →	-0.024	-2.993	.035	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Mesangial cells by PPP1R3B expression — UCEC

Explore this box plot interactively →