PPP1R3B

Across TCGA cell cohorts, PPP1R3B mutation is significantly associated with the mutation status of many other genes, with 3,756 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R3B-associated genes across cancer lineages are CTPS1, ATP8A2, and NRXN3. Each is linked with PPP1R3B in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R3B-to-partner and partner-to-PPP1R3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTPS1 grouped by PPP1R3B-low versus PPP1R3B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R3B→partner) and Y-score (partner→PPP1R3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CTPS1 →	+6.014	+6.014	.001	.001	1	3
LARGE_INTESTINE	ATP8A2 →	+2.630	+4.510	<.001	<.001	1	3
LARGE_INTESTINE	NRXN3 →	+2.099	+4.064	.001	.001	1	2
LARGE_INTESTINE	OSBPL5 →	+4.215	+3.874	<.001	<.001	1	2
LARGE_INTESTINE	LRRC7 →	+1.712	+3.676	.003	.003	1	2
LARGE_INTESTINE	VCAN →	+1.478	+3.408	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,756 associations by consensus.

CTPS1 by PPP1R3B expression — BLOOD_Lymphoma

Explore this box plot interactively →