PPP1R2P4

Across TCGA patient cohorts, PPP1R2P4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R2P4-associated genes across cancer lineages are Bax, PI3K-p85, and 4E-BP1_pT37_T46. Each is linked with PPP1R2P4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R2P4-to-partner and partner-to-PPP1R2P4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by PPP1R2P4-low versus PPP1R2P4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R2P4→partner) and Y-score (partner→PPP1R2P4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.298	+3.000	.031	.037	3	2
UCEC	PI3K-p85 →	+0.267	+3.000	.027	.037	3	1
UCEC	4E-BP1_pT37_T46 →	-0.857	-3.000	<.001	.037	2	1
UCEC	Annexin-1 →	+0.836	+3.000	.005	.037	1	1
UCEC	Rictor_pT1135 →	-0.149	-3.000	.011	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Bax by PPP1R2P4 expression — UCEC

Explore this box plot interactively →