PPP1R27

Across TCGA patient cohorts, PPP1R27 mutation is significantly associated with the RNA expression of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R27-associated genes across cancer lineages are RPL23AP90, TOMM22P1, and MIR4669. Each is linked with PPP1R27 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R27-to-partner and partner-to-PPP1R27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP90 grouped by PPP1R27-low versus PPP1R27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R27→partner) and Y-score (partner→PPP1R27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP90 →	+0.455	+3.762	.002	.002	3	1
SKCM	TOMM22P1 →	+0.144	+5.970	<.001	.002	3	1
UCEC	MIR4669 →	+0.571	+4.290	<.001	.001	3	1
UCEC	MIR5691 →	+0.543	+3.957	<.001	.002	3	1
UCEC	MIRLET7C →	+0.540	+3.599	<.001	.001	3	1
UCEC	RNA5SP319 →	+0.829	+3.646	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

RPL23AP90 by PPP1R27 expression — UCEC

Explore this box plot interactively →