PPP1R27

Across TCGA cell cohorts, PPP1R27 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,329 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PPP1R27-associated GO terms across cancer lineages are Regulation of translational elongation, Negative regulation of DNA-templated transcription, elongation, and Regulation of syncytium formation by plasma membrane fusion. Each is linked with PPP1R27 in more than 6 cancer types. Because this analysis shows association rather than direction, both PPP1R27-to-partner and partner-to-PPP1R27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational elongation grouped by PPP1R27-low versus PPP1R27-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R27→partner) and Y-score (partner→PPP1R27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of translational elongation →	+0.119	+0.188	<.001	.004	3	7
LUNG_NSCLC_LUSC	Negative regulation of DNA-templated transcription, elongation →	+0.116	+0.187	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.074	+0.236	.001	<.001	3	5
OESOPHAGUS	Basolateral protein secretion →	+0.170	+0.440	.003	.001	3	5
LARGE_INTESTINE	Negative regulation of transcription elongation by RNA polymerase II →	+0.088	+0.196	<.001	.009	3	5
BLOOD_Lymphoma	rRNA import into mitochondrion →	+0.115	+0.262	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,329 associations by consensus.

Regulation of translational elongation by PPP1R27 expression — LUNG_NSCLC_LUSC

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