PPP1R27

Across TCGA cell cohorts, PPP1R27 mutation is significantly associated with the mutation status of many other genes, with 430 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R27-associated genes across cancer lineages are HSD17B14, PIGS, and FXYD5. Each is linked with PPP1R27 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R27-to-partner and partner-to-PPP1R27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSD17B14 grouped by PPP1R27-low versus PPP1R27-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R27→partner) and Y-score (partner→PPP1R27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSD17B14 →	+5.523	+5.523	.003	.003	1	1
LARGE_INTESTINE	PIGS →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	FXYD5 →	+5.523	+5.523	.003	.003	1	1
LARGE_INTESTINE	ZBTB25 →	+5.523	+5.523	.003	.003	1	1
LARGE_INTESTINE	DHX32 →	+4.523	+5.087	.006	.006	1	1
LARGE_INTESTINE	ICAM1 →	+4.523	+5.087	.006	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 430 associations by consensus.

HSD17B14 by PPP1R27 expression — LARGE_INTESTINE

Explore this box plot interactively →