PPP1R21

Across TCGA pan-cancer cohorts, PPP1R21 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP1R21 data layer compared with 19 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPP1R21 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PPP1R21 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and UCEC are the cancer types where PPP1R21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.569	0.272	<.001	52	view →
HNSC	OS	Tertile	All	0.896	0.587	.001	45	view →
UCEC	OS	Quartile	II,III,IV	0.296	1.000	.031	22	view →
LUAD	DFS	Median	III,IV	1.000	0.498	.017	6	view →
CCRCC	OS	Median	III,IV	0.872	0.615	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PPP1R21–PDAC (OS)

Open the PDAC breakdown →