Across TCGA patient cohorts, PPP1R2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R2-associated genes across cancer lineages are EGFR_pY1068, EGFR, and FOXO3a_pS318_S321. Each is linked with PPP1R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R2-to-partner and partner-to-PPP1R2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R2→partner) and Y-score (partner→PPP1R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.265	-4.000	.012	<.001	3	1
UCEC	EGFR →	-0.176	-2.222	.009	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.122	-2.449	.021	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.211	-2.584	.003	.010	3	1
UCEC	JNK2 →	+0.184	+2.179	.029	.034	3	1
UCEC	Ku80 →	+0.295	+2.920	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

PPP1R2 survival (RNA) · tumor vs normal (RNA) · all PPP1R2 data types