PPP1R1B

Across TCGA pan-cancer cohorts, PPP1R1B mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPP1R1B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP1R1B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPP1R1B is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and COAD are the cancer types where PPP1R1B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R1B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−1.073	<.001	9	view →
LSCC	Female	All	−0.523	<.001	8	view →
COAD	Female	III,IV	−0.459	<.001	7	view →
LUAD	All	II,III,IV	+0.460	<.001	5	view →
PDAC	All	All	−0.440	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PPP1R1B–HNSC

Open the HNSC breakdown →