PPP1R1AP2

Across TCGA pan-cancer cohorts, PPP1R1AP2 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated PPP1R1AP2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PPP1R1AP2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPP1R1AP2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LUSC show a favorable association.

KIRC, BRCA, and KIRP are the cancer types where PPP1R1AP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.358	0.640	<.001	171	view →
BRCA	OS	Tertile	All	0.333	0.583	<.001	108	view →
KIRP	OS	Tertile	All	0.673	0.951	.001	57	view →
BLCA	DFS	Tertile	All	0.155	0.627	<.001	54	view →
UCS	OS	Tertile	All	0.174	0.592	.005	54	view →
THYM	DFS	Tertile	III,IV	0.205	0.774	.007	45	view →
ESCA	OS	Tertile	IV	0.095	0.512	.008	36	view →
LAML	DFS	Tertile	All	0.153	0.575	.030	36	view →
LUAD	DFS	Tertile	All	0.789	0.648	.025	21	view →
LUSC	DFS	Tertile	III,IV	0.882	0.449	.027	12	view →
SARC	OS	Tertile	All	0.175	0.730	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

PPP1R1AP2–KIRC (OS)

Open the KIRC breakdown →