PPP1R1AP1

Across TCGA pan-cancer cohorts, PPP1R1AP1 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated PPP1R1AP1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PPP1R1AP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PPP1R1AP1 expression acts as an unfavorable survival marker, although some lineages such as LAML and LGG show a favorable association.

KIRC, LIHC, and LUSC are the cancer types where PPP1R1AP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.357	0.574	.002	106	view →
LIHC	OS	Tertile	II,III,IV	0.059	0.772	<.001	54	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
KICH	OS	Tertile	II,III,IV	0.155	0.880	<.001	27	view →
PAAD	DFS	Tertile	All	0.237	0.503	<.001	18	view →
LUAD	DFS	Tertile	IV	0.333	0.671	.048	18	view →
LAML	DFS	Median	All	0.608	0.330	.010	14	view →
STAD	DFS	Quartile	IV	0.083	0.346	.004	3	view →
LGG	OS	Tertile	All	0.951	0.883	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

PPP1R1AP1–KIRC (OS)

Open the KIRC breakdown →