PPP1R18

Across TCGA pan-cancer cohorts, PPP1R18 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PPP1R18’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where PPP1R18 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PPP1R18 is over-expressed in tumor.

CCRCC, HNSC, and PDAC are the cancer types where PPP1R18 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R18 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+0.884	<.001	12	view →
HNSC	Male	All	+0.762	<.001	11	view →
PDAC	Female	All	+0.781	<.001	6	view →
LUAD	All	All	+0.096	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PPP1R18–CCRCC

Open the CCRCC breakdown →