PPP1R18

Across TCGA patient cohorts, PPP1R18 mutation is significantly associated with the RNA expression of many other genes, with 1,924 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R18-associated genes across cancer lineages are MIR4535, PGAM1, and LACTB. Each is linked with PPP1R18 in more than 2 cancer types. Because this analysis shows association rather than direction, both PPP1R18-to-partner and partner-to-PPP1R18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4535 grouped by PPP1R18-low versus PPP1R18-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R18→partner) and Y-score (partner→PPP1R18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR4535 →	+0.208	+4.186	<.001	.007	3	3
UCEC	PGAM1 →	+0.713	+2.828	.003	.001	3	3
UCEC	LACTB →	+0.553	+3.032	<.001	<.001	3	2
UCEC	BAG1 →	+0.614	+3.818	<.001	<.001	3	2
UCEC	TMEM33 →	+0.582	+3.606	<.001	.001	3	2
UCEC	NDUFC1 →	+0.378	+2.108	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,924 associations by consensus.

MIR4535 by PPP1R18 expression — SKCM

Explore this box plot interactively →