PPP1R18

Across TCGA cell cohorts, PPP1R18 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R18-associated genes across cancer lineages are RHCG, TACR3, and FAM216B. Each is linked with PPP1R18 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R18-to-partner and partner-to-PPP1R18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RHCG grouped by PPP1R18-low versus PPP1R18-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R18→partner) and Y-score (partner→PPP1R18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RHCG →	+0.099	+3.729	<.001	.009	3	1
BLOOD_Leukemia	TACR3 →	+0.030	+4.060	<.001	.003	3	1
BLOOD_Leukemia	FAM216B →	+0.146	+3.944	<.001	.006	3	1
BLOOD_Leukemia	OR1G1 →	+0.063	+3.705	<.001	.007	3	1
BLOOD_Leukemia	TEX35 →	+0.193	+3.769	<.001	.008	3	1
BREAST	OR10G2 →	+0.133	+4.672	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

RHCG by PPP1R18 expression — BLOOD_Leukemia

Explore this box plot interactively →