PPP1R17

Across TCGA patient cohorts, PPP1R17 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R17-associated genes across cancer lineages are GSK3-a-b, JNK_pT183_Y185, and JNK2. Each is linked with PPP1R17 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R17-to-partner and partner-to-PPP1R17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK3-a-b grouped by PPP1R17-low versus PPP1R17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R17→partner) and Y-score (partner→PPP1R17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK3-a-b →	+0.236	+3.169	.001	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.246	-3.156	.007	.020	3	1
UCEC	JNK2 →	+0.402	+3.026	<.001	.018	3	1
UCEC	MEK1 →	+0.467	+3.000	.020	.036	3	1
UCEC	STAT3_pY705 →	-0.502	-3.169	<.001	.020	3	1
UCEC	4E-BP1 →	+0.506	+2.837	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GSK3-a-b by PPP1R17 expression — UCEC

Explore this box plot interactively →