PPP1R15A

Across TCGA pan-cancer cohorts, PPP1R15A Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PPP1R15A data layer compared with 23 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PPP1R15A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PPP1R15A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP and UCEC are the cancer types where PPP1R15A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.188	0.770	.027	4	view →
UCEC	DFS	Median	II,III,IV	1.000	0.489	.047	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PPP1R15A–KIRP (OS)

Open the KIRP breakdown →