PPP1R14D

Across TCGA pan-cancer cohorts, PPP1R14D mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PPP1R14D’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPP1R14D mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPP1R14D is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, CCRCC, and LUAD are the cancer types where PPP1R14D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R14D mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.383	<.001	9	view →
CCRCC	Male	III,IV	+1.533	<.001	6	view →
LUAD	All	II,III,IV	+0.615	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PPP1R14D–COAD

Open the COAD breakdown →