Across TCGA pan-cancer cohorts, PPP1R14C Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PPP1R14C data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher PPP1R14C Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R14C expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

THCA and SKCM are the cancer types where PPP1R14C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.070	0.896	<.001	18	view →
SKCM	DFS	Median	All	1.000	0.603	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: PPP1R14C tumor-vs-normal RNA expression · all PPP1R14C data types