Across TCGA pan-cancer cohorts, PPP1R14C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP1R14C data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PPP1R14C mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R14C expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where PPP1R14C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.255	0.879	<.001	30	view →
LSCC	DFS	Median	II,III,IV	1.000	0.832	.004	21	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.911	.009	12	view →
PDAC	DFS	Median	IV	0.245	0.715	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PPP1R14C tumor-vs-normal RNA expression · all PPP1R14C data types