Across TCGA pan-cancer cohorts, PPP1R14C mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PPP1R14C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPP1R14C mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PPP1R14C is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

HNSC, PDAC, and LUAD are the cancer types where PPP1R14C tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1R14C mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.919	<.001	9	view →
PDAC	Male	All	+1.623	<.001	7	view →
LUAD	Male	All	−0.373	<.001	7	view →
LSCC	All	III,IV	+0.650	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PPP1R14C RNA expression & survival · all PPP1R14C data types