Across TCGA patient cohorts, PPP1R14C mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R14C-associated genes across cancer lineages are STAT3_pY705, XBP1, and beta-Catenin. Each is linked with PPP1R14C in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R14C-to-partner and partner-to-PPP1R14C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R14C→partner) and Y-score (partner→PPP1R14C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.356	-2.584	.003	.011	3	1
UCEC	XBP1 →	-0.174	-2.308	.008	.033	3	1
UCEC	beta-Catenin →	+0.508	+2.584	.031	.011	3	1
UCEC	Caspase-8 →	-0.275	-3.169	.018	.019	2	1
UCEC	4E-BP1 →	+0.313	+3.029	.013	.018	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

PPP1R14C survival (RNA) · tumor vs normal (RNA) · all PPP1R14C data types