PPP1R14A

Across TCGA patient cohorts, PPP1R14A mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PPP1R14A-associated genes across cancer lineages are MIR5588, LINC01810, and OR5H5P. Each is linked with PPP1R14A in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R14A-to-partner and partner-to-PPP1R14A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5588 grouped by PPP1R14A-low versus PPP1R14A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R14A→partner) and Y-score (partner→PPP1R14A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR5588 →	+0.968	+5.081	<.001	.008	3	2
SKCM	LINC01810 →	+0.094	+7.816	<.001	.008	3	1
SKCM	OR5H5P →	+0.034	+7.816	<.001	.008	3	1
COAD	RNU6-1187P →	+0.432	+5.080	<.001	.008	3	1
COAD	RNU6-975P →	+0.408	+5.017	.006	.009	3	1
COAD	HMGB3P13 →	+0.197	+5.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MIR5588 by PPP1R14A expression — UCEC

Explore this box plot interactively →