PPP1R12B

Across TCGA pan-cancer cohorts, PPP1R12B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPP1R12B data layer compared with 30 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPP1R12B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PPP1R12B expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where PPP1R12B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.506	0.301	<.001	97	view →
LUAD	DFS	Median	II,III,IV	0.773	1.000	.005	9	view →
CCRCC	OS	Tertile	II,III,IV	0.930	0.714	.016	8	view →
GBM	DFS	Tertile	All	0.837	0.674	.022	5	view →
UCEC	OS	Median	II,III,IV	0.647	1.000	.017	4	view →
HNSC	DFS	Quartile	II,III,IV	0.882	1.000	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PPP1R12B–PDAC (DFS)

Open the PDAC breakdown →