PPP1R12B

Across TCGA patient cohorts, PPP1R12B mutation is significantly associated with the RNA expression of many other genes, with 4,497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R12B-associated genes across cancer lineages are SNORD116-10, MIR6771, and MYO19. Each is linked with PPP1R12B in more than 3 cancer types. Because this analysis shows association rather than direction, both PPP1R12B-to-partner and partner-to-PPP1R12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-10 grouped by PPP1R12B-low versus PPP1R12B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R12B→partner) and Y-score (partner→PPP1R12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNORD116-10 →	+0.212	+5.153	<.001	.001	3	4
OV	MIR6771 →	+0.203	+4.748	.001	.005	3	3
SKCM	MYO19 →	+0.481	+2.254	.001	.006	3	3
SKCM	ATP1B2 →	-1.716	-3.546	.002	.002	3	3
UCEC	VRK1 →	+0.497	+2.386	<.001	<.001	3	3
UCEC	MLX →	+0.487	+2.917	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,497 associations by consensus.

SNORD116-10 by PPP1R12B expression — COAD

Explore this box plot interactively →