PPP1R12B

Across TCGA patient cohorts, PPP1R12B mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1R12B-associated genes across cancer lineages are eEF2, eIF4E, and GAPDH. Each is linked with PPP1R12B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R12B-to-partner and partner-to-PPP1R12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PPP1R12B-low versus PPP1R12B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R12B→partner) and Y-score (partner→PPP1R12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.294	+2.502	.003	.001	3	2
UCEC	eIF4E →	+0.180	+3.820	.002	<.001	3	2
UCEC	GAPDH →	+0.473	+2.169	.001	.002	3	2
UCEC	ACC1 →	+0.210	+1.054	.042	.029	3	2
UCEC	JNK_pT183_Y185 →	-0.152	-1.392	.001	.017	3	2
UCEC	JNK2 →	+0.208	+1.672	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by PPP1R12B expression — UCEC

Explore this box plot interactively →