PPP1R12B

Across TCGA cell cohorts, PPP1R12B mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPP1R12B-associated genes across cancer lineages are PNLIPRP1, CATSPERD, and MYH4. Each is linked with PPP1R12B in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1R12B-to-partner and partner-to-PPP1R12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNLIPRP1 grouped by PPP1R12B-low versus PPP1R12B-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1R12B→partner) and Y-score (partner→PPP1R12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PNLIPRP1 →	+0.035	+4.269	.001	.005	3	2
CNS	CATSPERD →	+0.132	+3.999	<.001	.004	3	2
CNS	MYH4 →	+0.014	+3.774	.009	.008	3	2
BREAST	CBLN4 →	+0.005	+4.312	<.001	.001	3	2
PANCREAS	OR6K2 →	+0.020	+4.614	<.001	.004	3	1
PANCREAS	SLC22A25 →	+0.011	+4.786	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

PNLIPRP1 by PPP1R12B expression — LUNG_SCLC

Explore this box plot interactively →