PPP1R12A

Across TCGA pan-cancer cohorts, PPP1R12A Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PPP1R12A data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPP1R12A Mutation is associated with better overall survival. In most high-consensus cancer types, elevated PPP1R12A expression acts as an unfavorable survival marker, although some lineages such as UCEC and LIHC show a favorable association.

UCEC, LUAD, and COAD are the cancer types where PPP1R12A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.975	0.645	.008	34	view →
LUAD	DFS	Median	All	0.260	0.772	<.001	27	view →
COAD	OS	Median	III,IV	0.167	0.799	<.001	27	view →
KIRP	DFS	Median	All	0.508	0.919	.030	9	view →
SKCM	DFS	Median	All	0.063	0.757	<.001	9	view →
MESO	DFS	Median	All	0.098	0.366	.039	6	view →
LIHC	DFS	Median	II,III,IV	1.000	0.198	.036	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PPP1R12A–UCEC (OS)

Open the UCEC breakdown →