PPP1R12A

Across TCGA pan-cancer cohorts, PPP1R12A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PPP1R12A data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PPP1R12A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1R12A expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where PPP1R12A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.234	0.904	.006	15	view →
CCRCC	DFS	Quartile	III,IV	0.907	0.498	.019	5	view →
HNSC	DFS	Quartile	All	0.569	0.858	.006	5	view →
UCEC	DFS	Median	II,III,IV	0.546	0.870	.047	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PPP1R12A–PDAC (DFS)

Open the PDAC breakdown →