Across TCGA pan-cancer cohorts, PPP1CC mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PPP1CC data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PPP1CC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1CC expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where PPP1CC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.484	0.757	.002	43	view →
LUAD	OS	Quartile	All	0.921	0.530	.012	18	view →
CCRCC	OS	Quartile	All	0.770	1.000	.034	5	view →
GBM	DFS	Median	All	0.460	0.287	.020	4	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.876	.040	3	view →
PDAC	OS	Median	IV	0.836	0.491	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: PPP1CC tumor-vs-normal RNA expression · all PPP1CC data types