Across TCGA patient cohorts, PPP1CC protein abundance is significantly associated with the RNA expression of many other genes, with 11,013 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PPP1CC-associated genes across cancer lineages are PXN-AS1, ANAPC7, and C12orf73. Each is linked with PPP1CC in more than 5 cancer types. Because this analysis shows association rather than direction, both PPP1CC-to-partner and partner-to-PPP1CC results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1CC→partner) and Y-score (partner→PPP1CC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PXN-AS1 →	+0.346	+0.242	<.001	<.001	3	6
LSCC	ANAPC7 →	+0.499	+0.256	<.001	<.001	3	5
HNSC	C12orf73 →	+0.609	+0.187	<.001	.006	2	6
GBM	C12orf45 →	+0.450	+0.250	<.001	<.001	3	5
HNSC	ATXN2 →	+0.517	+0.201	.002	.003	3	5
OV	VPS29 →	+0.453	+0.326	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,013 associations by consensus.

Exploration

PPP1CC survival (RNA) · tumor vs normal (RNA) · all PPP1CC data types