Across TCGA patient cohorts, PPP1CC mutation is significantly associated with the RNA expression of many other genes, with 1,840 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1CC-associated genes across cancer lineages are RNA5SP412, MTATP6P4, and SRXN1. Each is linked with PPP1CC in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1CC-to-partner and partner-to-PPP1CC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1CC→partner) and Y-score (partner→PPP1CC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.723	+2.315	<.001	.002	3	2
COAD	MTATP6P4 →	+0.089	+5.721	<.001	.001	3	2
UCEC	SRXN1 →	+0.741	+2.375	<.001	.003	3	1
UCEC	RPL23AP90 →	+0.396	+2.645	<.001	<.001	3	1
UCEC	CWC25 →	+0.487	+3.600	<.001	.001	3	1
UCEC	MIR7702 →	+0.202	+4.060	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,840 associations by consensus.

Exploration

PPP1CC survival (RNA) · tumor vs normal (RNA) · all PPP1CC data types