Across TCGA patient cohorts, PPP1CC mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1CC-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and GAPDH. Each is linked with PPP1CC in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1CC-to-partner and partner-to-PPP1CC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1CC→partner) and Y-score (partner→PPP1CC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.323	+2.584	.007	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.199	-3.575	<.001	.002	3	1
UCEC	GAPDH →	+0.568	+2.999	.023	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.250	-3.459	.001	.005	3	1
UCEC	Ku80 →	+0.320	+2.598	.003	.006	3	1
UCEC	mTOR_pS2448 →	-0.182	-3.302	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

PPP1CC survival (RNA) · tumor vs normal (RNA) · all PPP1CC data types