Across TCGA pan-cancer cohorts, PPP1CB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PPP1CB data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PPP1CB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PPP1CB expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where PPP1CB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	III,IV	0.277	1.000	.010	16	view →
HNSC	DFS	Tertile	III,IV	0.936	0.697	.007	10	view →
CCRCC	DFS	Median	All	0.722	0.881	.015	5	view →
LUAD	OS	Median	All	0.821	0.580	.044	2	view →
LSCC	DFS	Quartile	All	0.344	0.800	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PPP1CB tumor-vs-normal RNA expression · all PPP1CB data types