Across TCGA patient cohorts, PPP1CB mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPP1CB-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and Gab2. Each is linked with PPP1CB in more than 1 cancer types. Because this analysis shows association rather than direction, both PPP1CB-to-partner and partner-to-PPP1CB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPP1CB→partner) and Y-score (partner→PPP1CB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.259	-2.169	.005	.003	3	1
UCEC	A-Raf_pS299 →	-0.094	-2.459	.035	.019	3	1
UCEC	Gab2 →	+0.338	+1.415	.011	.046	3	1
UCEC	INPP4B →	-0.311	-2.156	.010	.003	3	1
UCEC	Ku80 →	+0.229	+1.778	.009	.008	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.534	-2.807	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

PPP1CB survival (RNA) · tumor vs normal (RNA) · all PPP1CB data types