PPP1CA

Across TCGA pan-cancer cohorts, PPP1CA mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PPP1CA’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PPP1CA mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PPP1CA is over-expressed in tumor.

COAD, HNSC, and PDAC are the cancer types where PPP1CA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPP1CA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.418	<.001	11	view →
HNSC	Male	II,III,IV	+0.417	<.001	11	view →
PDAC	Female	All	+0.525	<.001	7	view →
LUAD	Female	All	+0.136	<.001	5	view →
OV	All	All	+0.343	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PPP1CA–COAD

Open the COAD breakdown →